S7 E6: Weight Regain with GLP1ra; Orforglipron; Ivermectin vs Permethrin
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PHARMACEUTICAL INFLUENCE
16th January 2026
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Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we have three new and interesting research papers to look at.
First, hitting the headlines this week, weight regain after cessation of GLP1 receptor agonists. Not a surprise, perhaps, but how fast does the weight come back, can anything be done to prevent it, and what are the implications for patients and the NHS?
Second, orforglipron - the new GLP1ra on the block and an oral treatment. Can it help weight loss and improvement in cardiometabolic markers in patients with obesity and type 2 diabetes?
Finally, which is better for treating scabies - permethrin or oral ivermectin? Would a tablet be an easier option, or is it just not as good?
References
BMJ Weight regain after cessation of weight loss medications
NEJM Orforglipron RCT in obesity
Lancet Orforglipron RCT in obesity and T2DM
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